Publications

2024

Simpson, M. S., De Luca, H., Cauthorn, S., Luong, P., Udeshi, N. D., Svinkina, T., Schmieder, S. S., Carr, S. A., Grey, M. J., & Lencer, W. I. (2024). IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response. The Journal of cell biology, 223(7), e202402062.

2023

Maeda K, Bugda Gwilt K, Schmieder SS, Zachos NC, Lencer WI. Protocol for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal organoids [published online ahead of print, 2023 May 25]. STAR Protoc. 2023;4(2):102335.

2022

Grey, M. J., De Luca, H., Ward, D. V., Kreulen, I. A., Bugda Gwilt, K., Foley, S. E., Thiagarajah, J. R., McCormick, B. A., Turner, J. R., & Lencer, W. I. (2022). The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development. The Journal of clinical investigation, 132(17), e153519.

Schmieder, S. S., Tatituri, R., Anderson, M., Kelly, K., & Lencer, W. I. (2022). Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Cell reports, 40(2), 111063.

Maeda, K., Zachos, N. C., Orzalli, M. H., Schmieder, S. S., Chang, D., Bugda Gwilt, K., Doucet, M., Baetz, N. W., Lee, S., Crawford, S. E., Estes, M. K., Kagan, J. C., Turner, J. R., & Lencer, W. I. (2022). Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell host & microbe, 30(2), 216–231.e5

Maeda, K., Bugda Gwilt, K., Schmieder, S. S., Zachos, N. C., & Lencer, W. I. (2023). Protocol for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal organoids. STAR protocols, 4(2), 102335. Advance online publication.

2021

Cloots, E., Simpson, M. S., De Nolf, C., Lencer, W. I., Janssens, S., & Grey, M. J. (2021). Evolution and function of the epithelial cell-specific ER stress sensor IRE1β. Mucosal immunology, 14(6), 1235–1246.

Gustafsson, J. K., Davis, J. E., Rappai, T., McDonald, K. G., Kulkarni, D. H., Knoop, K. A., Hogan, S. P., Fitzpatrick, J. A., Lencer, W. I., & Newberry, R. D. (2021). Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife, 10, e67292.

Chang, D., Luong, P., Li, Q., LeBarron, J., Anderson, M., Barrett, L., & Lencer, W. I. (2021). Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies. The Journal of cell biology, 220(9), e202007177.

Kenworthy, A. K., Schmieder, S. S., Raghunathan, K., Tiwari, A., Wang, T., Kelly, C. V., & Lencer, W. I. (2021). Cholera Toxin as a Probe for Membrane Biology. Toxins, 13(8), 543.

2020

Chang, D., Whiteley, A. T., Bugda Gwilt, K., Lencer, W. I., Mekalanos, J. J., & Thiagarajah, J. R. (2020). Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27502–27508.

Simpson, M. S., Lencer, W. I., & Luong, P. (2020). A Quantitative Single-cell Flow Cytometry Assay for Retrograde MembraneTrafficking Using Engineered Cholera Toxin. Bio-protocol, 10(15), e3707.

Lencer W. I. (2020). Everything Illuminated-Clostridium perfringens β-toxin. Cell host & microbe, 28(1), 5–6.

Kabbani, A. M., Raghunathan, K., Lencer, W. I., Kenworthy, A. K., & Kelly, C. V. (2020). Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin. Proceedings of the National Academy of Sciences of the United States of America, 117(26), 14978–14986.

Duclos, R. I., Jr, Blue, K. D., Rufo, M. J., Chen, X., Guo, J. J., Ma, X., Lencer, W. I., & Chinnapen, D. J. F. (2020). Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers. Bioorganic & medicinal chemistry letters, 30(8), 127014.

Luong, P., Li, Q., Chen, P. F., Wrighton, P. J., Chang, D., Dwyer, S., Bayer, M. T., Snapper, S. B., Hansen, S. H., Thiagarajah, J. R., Goessling, W., & Lencer, W. I. (2020). A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Molecular biology of the cell, 31(7), 511–519.

Grey, M. J., Cloots, E., Simpson, M. S., LeDuc, N., Serebrenik, Y. V., De Luca, H., De Sutter, D., Luong, P., Thiagarajah, J. R., Paton, A. W., Paton, J. C., Seeliger, M. A., Eyckerman, S., Janssens, S., & Lencer, W. I. (2020). IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress. The Journal of cell biology, 219(2), e201904048.

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